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FENS Forum 2008 - Geneva

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First author: Hyland, Brian I. (poster)

Poster board D56 - Wed 16/07/2008, 11:30 - Hall 1
Session 222 - Basal ganglia
Abstract n° 222.15
Publication ref.: FENS Abstr., vol.4, 222.15, 2008

Authors Hyland B. (1), Dejean C. (2), Sheerin A. (1), Arbuthnott G. (2, 3) & Wickens J. (2, 3)
Addresses (1) Physiol. Dept., Dunedin, New Zealand; (2) Dept. Anat. Struct. Biol., Dunedin, New Zealand; (3) OIST, Okinawa, Japan
Title Gamma- and beta-oscillations in rat globus pallidus are differentially modulated during immobility induced by dopamine D2- or D1- receptor antagonists.
Text The external globus pallidus may be important for generation and/or transmission of normal and pathological oscillations in the basal ganglia-cortex network. However little is known of the expression of local field potential oscillations in this structure in unanesthetized animals. We recorded local field potentials from chronically implanted electrodes before and after induction of parkinsonian akinesia by acute blockade of dopamine receptors with selective D1 (SCH23390) or D2 (raclopride) antagonists. The results revealed prominent power in the gamma band (45 – 80 Hz) in freely moving rats, which was significantly decreased during akinesia following D2-receptor blockade, but was not changed during akinesia induced by a D1 antagonist. In contrast, akinesia induced by both drugs was associated with an increase in power in the beta band (15-30 Hz). These results support the hypothesis that gamma frequency oscillations are a D2-dependent phenomenon that may therefore originate within the indirect pathway through the basal ganglia, whereas the finding that beta power was equally modulated during D1- and D2 antagonist treatment suggest that interactions within the indirect pathway may not be fundamental in the generation of oscillations in this frequency band, consistent with suggestions that beta oscillations may originate elsewhere, such as in the cortex.
Theme D - Sensory and motor systems
Basal ganglia

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